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On the basis of these selection criteria, two large well known ASD risk loci emerged that harboured multiple duplications in the Prader Willi/Angelman syndrome (15q11 13) critical region, and multiple deletions were detected in the DiGeorge syndrome (22q11) critical region, albeit notably smaller than the 22q11 deletion syndrome. A third locus harbouring deletions in poly ADP ribose polymerase family 8 (PARP8) on chromosome 5q11 was also discovered. PARP8 was previously identified as associated with the ASDs in a Dutch population47, but it has not previously been described for its pan ethnic distribution across European derived and African derived populations.We examined the genetic interaction networks derived from gene salvatore ferragamo belts india online families with members localized to the the Prader Willi/Angelman syndrome (15q11 13) critical region, the DiGeorge syndrome (22q11) critical region, and the novel PARP8 (5q11) region using a method previously applied to ADHD30; however, hardly any of the most significant genes harbouring significant CNVRs clustered within gene families.
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